These are not all the side effects with DETROL LA. For a complete list, ask your doctor or pharmacist. ECG monitoring is recommended in the event of overdosage. Frequent urination with an abnormally large amount of urine is often an early symptom of both type 1 and as the body tries to rid itself of unused glucose through the urine. Dose reduction or discontinuation should be considered if CNS effects occur. The active substance in Detrusitol is tolterodine. canada condylox high condylox
The two often coexist in women. Should not be used in patients with these conditions. Panobinostat: May increase the serum concentration of CYP2D6 Substrates. Management: Avoid concurrent use of sensitive CYP2D6 substrates when possible, particularly those substrates with a narrow therapeutic index. How should I take DETROL?
VinBLAStine: May increase the serum concentration of Tolterodine. With age, you're more at risk for OAB. Women are more likely to be affected by the condition earlier in life than are men. Most men with OAB are age 65 and above, but the condition begins to increase among women when they are in their mid-40s. How often did hospital staff describe possible side effects in a way you could understand?
Siltuximab: May decrease the serum concentration of CYP3A4 Substrates. DETROL. If you would like more information, talk with your doctor. Potassium passes into milk. Consult your doctor before -feeding. Weight gain 1%; peripheral edema postmarketing.
The extended release formulation should be swallowed whole. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? If you take pramlintide with medicines that speed up the movement of food through your stomach, your pramlintide may not work as well. Cimetropium: Anticholinergic Agents may enhance the anticholinergic effect of Cimetropium. Approximately 93% of Caucasians exhibit the extensive-oxidizer phenotype and about 7% exhibit the poor-oxidizer phenotype. Brynne N, Stahl MMS, Hallén B et al. Pharmacokinetics and pharmacodynamics of tolterodine in man: a new drug for the treatment of urinary bladder overactivity. Int J Clin Pharmacol Ther. Antagonizes muscarinic receptor, which mediates urinary bladder contraction. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. DETROL LA is 2 mg once daily. In healthy volunteers, coadministration of tolterodine immediate-release 4 mg 2 mg bid for 7 days and a single dose of warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Following administration of a 5-mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days. You have an eye problem called “uncontrolled narrow-angle glaucoma”. What should I tell my doctor before starting tolterodine tartrate extended-release capsules? Many people are too shy to talk about their bladder problems. But overactive bladder can get better with treatment. Don't be afraid to talk with your doctor about how to control your overactive bladder. What causes overactive bladder? Talk to your doctor about using tolterodine safely. There are no studies of tolterodine in pregnant women. Your bladder will need some time to adapt. If you have not noticed any effect by then, talk to your doctor. trihexyphenidyl
Conivaptan: May increase the serum concentration of CYP3A4 Substrates. Mirabegron may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use mirabegron with caution. Table 2 summarizes the mean change from baseline to steady state in corrected QT interval QTc relative to placebo at the time of peak tolterodine 1 hour and moxifloxacin 2 hour concentrations. The effect of 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were poor metabolizers see for discussion of poor metabolizers. Then there was the elevator incident, one of life's most embarrassing moments. Dunn was standing on an elevator with a stranger when the urge hit. Crossing her legs didn't prevent the puddle on the floor.
Overactive bladder can play havoc with how you feel about yourself, not to mention your daily work schedule and social life. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Bloody or cloudy urine. No single QT correction method is known to be more valid than others. Importance of informing patients of other important precautionary information. See Cautions. It is not known whether tolterodine is excreted in human milk; therefore, tolterodine tartrate extended-release capsules should not be administered during nursing. A decision should be made whether to discontinue nursing or to discontinue tolterodine tartrate extended-release capsules in nursing mothers. can you pletal in australia
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Xerophthalmia 3%; abnormal accommodation 2%; abnormal vision 1%. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious problems. In rare cases when all OAB treatment fails and overactive bladder is severe, doctors may recommend one of several types of surgery. A procedure called bladder augmentation uses part of the bowel to increase bladder capacity. Lou Dunn is one of those women who's always on the go. The Pittsburgh mother and wife runs her own calligraphy business and usually has energy to burn. DETROL LA 4 mg once daily. Gosselin RE, Smith RP, Hodge HC et al. Clinical toxicology of commercial products. Detrol Tablets were evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency in four randomized, double-blind, placebo-controlled, 12-week studies. A total of 853 patients received Detrol 2 mg twice daily and 685 patients received placebo. The majority of patients were Caucasian 95% and female 78% with a mean age of 60 years range, 19 to 93 years. At study entry, nearly all patients perceived they had urgency and most patients had increased frequency of micturitions and urge incontinence. These characteristics were well balanced across treatment groups for the studies. Tolterodine tartrate extended-release capsules for oral administration contains 2 mg or 4 mg of tolterodine tartrate. Inactive ingredients include: ethylcellulose, gelatin, hydroxypropyl cellulose, hypromellose, iron oxide black, propylene glycol, shellac glaze, sugar spheres which contain sucrose and corn starch titanium dioxide, and triethyl citrate. Use with caution in patients with decreased GI motility. The initial recommended dose of Detrol Tablets is 2 mg twice daily. The dose may be lowered to 1 mg twice daily based on individual response and tolerability. Severe. These medicines may interact and cause very harmful effects and are usually not taken together. This should help lessen the urgency and give you more time to get to the toilet, he says. Distribution: Tolterodine is highly bound to plasma proteins, primarily α 1-acid glycoprotein. Tolterodine Tartrate Tablets may cause allergic reactions that may be serious. Symptoms of a serious allergic reaction may include swelling of the face, lips, throat or tongue. If you experience these symptoms, you should stop taking Tolterodine Tartrate Tablets and get emergency medical help right away.
If you are pregnant or trying to become pregnant. It is not known if Tolterodine Tartrate Tablets could harm your unborn baby. Another type of drug for overactive bladder is the tricyclic hydrochloride which also relaxes bladder muscles. International Painful Bladder Foundation: "The Urinary Tract and How It Works. Stiripentol: May increase the serum concentration of CYP3A4 Substrates. Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring. Diet changes. One way to start is to change the liquid you put in your body every day. HMT in extensive EM and poor PM metabolizers is provided in Table 3. These data were obtained following single and multiple doses of tolterodine extended release administered daily to 17 healthy male volunteers 13 EM, 4 PM. The 1 mg tablets are white, film-coated, round, unscored tablets debossed with M on one side of the tablet and TT1 on the other side. Have an eye problem called narrow-angle glaucoma. Secretin: Anticholinergic Agents may diminish the therapeutic effect of Secretin. Management: Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combination, monitor closely for a diminished response to secretin. In that case, omit the forgotten dose and follow the normal dose schedule. Loyola University Chicago Stritch School of Medicine, and director of the division of female pelvic medicine and reconstructive surgery at Loyola University Health System. "We could give you that help with urge incontinence, but you might still be bothered by stress. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Tell your doctor if your condition persists or worsens. The frequency of discontinuation due to adverse events was highest during the first 4 weeks of treatment. Seven percent of patients treated with Detrol 2 mg bid discontinued treatment due to adverse events versus 6% of placebo patients. The most common adverse events leading to discontinuation of Detrol were dizziness and headache. If it bothers you to get up at night to urinate, cut down on fluids before bed. But don't cut down on fluids at other times of the day. You need them to stay healthy. gefitinib australia price
HMT, the pharmacologically active metabolite of tolterodine. Do not keep outdated medicine or medicine no longer needed. Elimination half-life of tolterodine prolonged in patients with hepatic impairment. 1 10 See Hepatic Impairment under Dosage and Administration. Both men and women can have it, but it's more common in women. PO Use is not recommended. QD, tolterodine 2 mg BID, tolterodine 4 mg BID, and placebo. The 4 mg BID dose of tolterodine IR two times the highest recommended dose was chosen because this dose results in tolterodine exposure similar to that observed upon coadministration of tolterodine 2 mg BID with potent CYP3A4 inhibitors in patients who are CYP2D6 poor metabolizers see . QT interval was measured over a 12-hour period following dosing, including the time of peak plasma concentration T max of tolterodine and at steady state Day 4 of dosing. Overdose symptoms may include dry mouth, blurred vision, and fast heartbeat. What should I avoid while taking tolterodine? Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and herbal supplements, as well as any concomitant illnesses. Symptoms may include fast or irregular heartbeat; severe or persistent headache or dizziness. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Bladder relaxants don't cure overactive bladder, but they can relieve the symptoms. Dasatinib: May increase the serum concentration of CYP3A4 Substrates. Have any stomach or intestinal problems. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Other drugs can affect how your body handles tolterodine tartrate extended-release capsules.
Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed. Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates. Management: Concurrent use of enzalutamide with CYP3A4 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring. DETROL may cause allergic reactions that may be serious. This list is not complete and there are many other drugs that can interact with tolterodine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. QT interval is unclear. Ask your doctor or pharmacist for a list of these medicines, if you are not sure. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure. neurontin
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Known hypersensitivity to tolterodine or any ingredient in the formulation. The most common adverse events reported by patients receiving tolterodine tartrate extended-release capsules were dry mouth, headache, constipation, and abdominal pain. Detrol Tablets for oral administration contain 1 or 2 mg of tolterodine tartrate. Usually the benefits of the medicine are more important than any minor side effects. With the right approach, you can get a handle on these issues. Use with caution in patients with clinically significant bladder outflow obstruction, GI obstructive disorders eg, pyloric stenosis decreased GI motility eg, intestinal atony controlled narrow-angle glaucoma, or myasthenia gravis. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
PHARMACIST: Dispense a Patient Information Leaflet with each prescription. Are you experiencing other symptoms? The presence of other medical problems may affect the use of this medicine. Taking a road trip? Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take. fluticasone medicine
AUC of tolterodine and its 5-HMT metabolite. At these exposure margins, no increase in tumors was found in either mice or rats. Are pregnant or trying to become pregnant. It is not known if tolterodine tartrate extended-release capsules could harm your unborn baby. Use it after each time you urinate, she says. Dry mouth is common with these medicines. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; chest pain; confusion; difficult or painful urination; disorientation; fainting; fast or irregular heartbeat; hallucinations; memory problems; severe dizziness; swelling of the hands, ankles, or feet. If possible, get your bladder ready several weeks before you travel with these bladder-training techniques.
The pharmacokinetics of tolterodine have not been established in pediatric patients. It belongs to a class of drug called anticholinergics. It is the first of this class to go over-the-counter for overactive bladder treatment. Keep Detrusitol out of the sight and reach of children. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Anaphylaxis and angioedema requiring hospitalization and emergency medical treatment have occurred with the first or subsequent doses of tolterodine tartrate extended-release capsules. In the event of difficulty in breathing, upper airway obstruction, or fall in blood pressure, tolterodine tartrate extended-release capsules should be discontinued and appropriate therapy promptly provided. Keep DETROL LA and all medicines out of the reach of children. Tolteridinhydrochlorid PH: Ph. Eur. What are the ingredients in tolterodine tartrate extended-release capsules? The review does not make recommendations about the use of these drugs. Yet with proper management and trip preparations, you can travel with less fear of toileting accidents. Robert L. Kane, MD, a professor of long-term care and aging at the University of Minnesota? Your doctor will tell you how many Detrol Tablets to take and when to take them. spod.info estrace
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The remainder of the population is referred to as "extensive metabolizers. An extra patient leaflet is available with Detrol. Talk to your pharmacist if you have questions about this information. Tolterodine Tartrate Tablets should be used with caution in patients being treated for narrow-angle glaucoma.
With PTNS, you'll need a series of 12 treatments, scheduled about a week apart. You may need more than one treatment to keep seeing results. Tolterodine has a pronounced effect on bladder function. The electrical current may also encourage the growth of nerve cells that cause the muscles to contract.
It is not known if tolterodine, the active substance of Detrusitol, is excreted in the mother's breast milk. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Upjohn Co, Division of Pfizer Inc, NY, NY 10017. The difference between Tolterodine Tartrate Tablets and placebo was statistically significant.
Plasma levels of tolterodine may be increased; no dosage adjustment is required. Take Tolterodine Tartrate Tablets at the same times each day. St John's Wort: May decrease the serum concentration of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Nothing on the outside should move.